Key result
Circulating plasma thrombomodulin peaks at ~165 ng/ml during gestation and declines steadily through childhood.
Why the study?
The pattern and levels of circulating plasma thrombomodulin during human foetal maturation and childhood were not well characterized.
Population
Human foetuses at different pregnancy stages, at birth, and children aged 5-15 years
Comparison
Circulating plasma thrombomodulin levels across gestational ages and childhood
Design
Observational cross-sectional study
Authors
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Fetal pTM trajectory data support developmental hemostasis research; leaves open any clinical biomarker role.
Observational
Plasma thrombomodulin levels peak during mid-gestation and decline through childhood, suggesting a specific developmental role in foetuses beyond its known anticoagulant function.
Aurousseau et al. (1999) reported an observational. Developmental stage was evaluated on Circulating plasma thrombomodulin (pTM) levels. Circulating plasma thrombomodulin levels peaked at ~165 ng/ml between the 23rd and 26th week of gestation, decreasing to 108 ng/ml at birth and 56 ng/ml in children aged 5-15 years.
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