Key result
The PAUSE study is designed to evaluate the safety of a standardized perioperative DOAC management protocol, defined by expected risks of major bleeding of 1% and arterial thromboembolism of 0.5%.
Why the study?
Does a standardized perioperative management protocol safely guide DOAC interruption in patients with atrial fibrillation undergoing elective procedures?
Cohort (n=3,300)
Yes
Does a standardized perioperative management protocol safely guide DOAC interruption in patients with atrial fibrillation undergoing elective procedures?
The PAUSE study is designed to evaluate a standardized, patient-specific perioperative management protocol for DOAC interruption in patients with atrial fibrillation.
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Provides framework for DOAC interruption in elective AF procedures; leaves open whether 1%/0.5% safety thresholds are met in practice.
Douketis et al. (2017) conducted a cohort in Atrial fibrillation requiring elective surgery or procedure (n=3,300). Standardized perioperative DOAC management protocol was evaluated on Arterial thromboembolism and major bleeding. The PAUSE study is designed to evaluate the safety of a standardized perioperative DOAC management protocol, defined by expected risks of major bleeding of 1% and arterial thromboembolism of 0.5%.
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