Clinical outcomes of cancer-associated isolated distal deep vein thrombosis: a comparison between asymptomatic and symptomatic thrombosis—findings from the ONCO DVT Study

Figure 1. Study flow chart. Patients were divided into asymptomatic and symptomatic groups based on the presence or absence of symptoms associated with isolated distal deep vein thrombosis at diagnosis.

Figure 2. Kaplan–Meier curves for persistent edoxaban discontinuation in asymptomatic and symptomatic groups. Persistent edoxaban discontinuation was defined as the withdrawal of edoxaban according to the study protocol or lasting for more than 14 days for any reason. IDDVT, isolated distal deep vein thrombosis.

Figure 3. Kaplan–Meier curves for the primary outcome in asymptomatic and symptomatic groups. The primary outcome consisted of symptomatic recurrent VTE or VTE-related death. IDDVT, isolated distal deep vein thrombosis; VTE, venous thromboembolism.

Figure 4. Kaplan–Meier curves for major bleeding in asymptomatic and symptomatic groups. Major bleeding was defined according to the definition of the International Society on Thrombosis and Haemostasis criteria, which consisted of fatal bleeding, symptomatic bleeding in a critical area or organ, and bleeding causing a reduction in the level of hemoglobin by at least 2 g/dL or leading to a transfusion of at least 2 units of whole blood or red cells. IDDVT, isolated distal deep vein thrombosis.