Asymptomatic Lower Extremity Deep Vein Thrombosis ― Clinical Characteristics, Management Strategies, and Long-Term Outcomes ―
Why the study?
Does prolonged anticoagulant therapy reduce recurrent VTE or increase bleeding in patients with asymptomatic lower extremity DVT?
Population
300 patients with asymptomatic lower extremity DVT screened from 4,514 consecutive patients on ultrasound at…
Comparison
Prolonged anticoagulant therapy vs No anticoagulant therapy
Design
Cohort
Follow-up
5 years
Authors
Discussion
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Member takes
Implication
Anticoagulation for asymptomatic DVT raises major bleeding risk without clear overall VTE benefit; leaves open possible value in active cancer.
Structured PICO
Does prolonged anticoagulant therapy reduce recurrent VTE or increase bleeding in patients with asymptomatic lower extremity DVT?
P
Population
300 patients with asymptomatic lower extremity DVT screened from 4,514 consecutive patients on ultrasound at Kyoto University Hospital. 40% had concomitant active cancer, 59% unprovoked DVT, and 70% distal DVT.
I
Intervention
Prolonged anticoagulant therapy
C
Comparator
No anticoagulant therapy
O
Outcome
Cumulative 5-year incidences of symptomatic recurrent venous thromboembolism (VTE), major bleeding, and all-cause deathhard clinical
Prolonged anticoagulant therapy for asymptomatic lower extremity DVT increases major bleeding risk without overall VTE benefit, though it may reduce recurrent VTE in patients with active cancer.
Cite This Study
Yamashita et al. (2017) studied this question.