Why the study?
The study aimed to ascertain the comorbidity profile of non-obese patients with newly diagnosed OSA, evaluate their risk for cardiovascular disease and mortality, and establish predictors for OSA severity.
Is obstructive sleep apnea severity associated with increased 10-year cardiovascular risk and comorbidity burden in non-obese patients?
Population
138 newly diagnosed patients undergoing polysomnography (86 males and 52 females)
Comparison
Mild vs moderate vs severe OSA vs controls (AHI < 5)
Design
Observational cross-sectional study
Key result
Non-obese patients with obstructive sleep apnea had significantly higher 10-year cardiovascular risk (SCORE-2, p<0.001) and comorbidity burden (CCI, p=0.001) compared to controls without OSA.
Authors
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OSA severity links to higher CV risk in non-obese patients; hypothesis-generating and requires prospective trials before practice change.
Observational (n=138)
Is obstructive sleep apnea severity associated with increased 10-year cardiovascular risk and comorbidity burden in non-obese patients?
p-value: p=<0.001
In non-obese patients, increasing severity of obstructive sleep apnea is associated with a higher 10-year predicted risk of cardiovascular disease and greater comorbidity burden.
Ivanovski et al. (2023) conducted an observational in Non-obese obstructive sleep apnea (OSA) (n=138). Obstructive sleep apnea (severity based on AHI) vs. Control group (AHI < 5) was evaluated on 10-year risk for cardiovascular disease (SCORE-2) (p=<0.001). Non-obese patients with obstructive sleep apnea had significantly higher 10-year cardiovascular risk (SCORE-2, p<0.001) and comorbidity burden (CCI, p=0.001) compared to controls without OSA.