Key result
Growth hormone yields smaller, less consistent height gains in non-deficient short stature versus classical deficiency.
Why the study?
Despite growing clinical demand, GH treatment for non-GHD causes of short stature has shown less consistent and less dramatic effects on adult height, reflecting biological constraints.
Does growth hormone treatment improve adult height in children with non-GH-deficient short stature?
Does growth hormone treatment improve adult height in children with non-GH-deficient short stature?
Answers are grounded in this paper and cite their sources.
Growth hormone treatment for non-GH-deficient short stature yields less consistent and dramatic effects on adult height compared to classical GH deficiency.
The success of growth hormone (GH) replacement in children with classical GH deficiency has led to excitement that other causes of short stature may benefit similarly. However, clinical experience has shown less consistent and generally less dramatic effects on adult height, perhaps not surprising in light of increased understanding of GH and growth plate biology. Nonetheless, clinical demand for GH treatment continues to grow. Upon the 20th anniversary of the US Food and Drug Administration's approval of GH treatment for idiopathic short stature, this review will consider the factors underlying the expansion of GH treatment, the biological mechanisms of GH action, the non-GH-deficient uses of GH as a height-promoting agent, biological constraints to GH action, and future directions.
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Grimberg et al. (2023) conducted a review in Non-growth hormone deficiency (GHD) short stature disorders. Growth hormone (GH) was evaluated on Adult height. Growth hormone treatment for non-growth hormone deficient short stature disorders yields less dramatic and less consistent adult height gains compared to classical growth hormone deficiency.
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