Key result
Myocardial hypoperfusion on emergency CT strongly correlates with corresponding vascular territories on ICA.
Why the study?
The diagnostic value of CT myocardial hypoperfusion for the detection of acute myocardial infarction is still not well evaluated.
Does incidental myocardial hypoperfusion on emergency CT imaging correlate with acute myocardial infarction on invasive coronary angiography?
Observational (n=22)
No
Does incidental myocardial hypoperfusion on emergency CT imaging correlate with acute myocardial infarction on invasive coronary angiography?
Effect estimate: ρ = 0.73
p-value: p=< 0.001
Incidental myocardial hypoperfusion on emergency CT strongly correlates with acute myocardial infarction on invasive angiography, highlighting the need for rapid targeted cardiological workup to reduce CT-to-catheter time.
May support urgent cardiology referral for incidental CT hypoperfusion; leaves open prospective validation of outcome benefit.
Emergency computed tomography (CT) often does not allow for comprehensive coronary artery assessment. However, CT may reveal pathological myocardial hypoperfusion suggestive of acute myocardial infarction (AMI), especially in patients presenting with a different diagnostic hypothesis. CT hypoperfusion is known to be associated with myocardial infarction, however the diagnostic value of CT hypoperfusion for the detection of AMI is still not well evaluated. This was a single-centre retrospective study including patients who underwent invasive coronary angiography (ICA) due to suspected AMI based on incidental perfusion defects upon emergency CT imaging between 2018 and 2023. A total of 22 patients (mean age 66.3 ± 10.8 years, 11 female) were included in this analysis. The diagnosis of AMI was established in all cases leading to ICA. Culprit coronary artery lesions with an indication of percutaneous coronary intervention were detected in all patients who underwent ICA. Spearmann correlation for hypoperfused segments on CT imaging and the corresponding vascular territory upon ICA was significantly substantial (ρ = 0.73, p = < 0.001). The higher the number of affected myocardial segments, the faster ICA was initiated. Mean time between the suspicion of AMI on CT imaging and ICA was 196 (29-4044) minutes. Myocardial hypoperfusion on emergency CT imaging should be considered as AMI until proven otherwise, independent of the clinical scenario leading to performance of CT imaging and whether imaging was performed for the exclusion of non-cardiac pathologies. Early initiation of further diagnostic workup may potentially avoid delays to invasive treatment and reduce the CT-to-catheter-time. Our study explicitly underlines that myocardial hypoperfusion upon contrast enhanced CT imaging needs to be considered as sign of acute myocardial infarction and indicates targeted clinical workup to rule out this diagnosis and to shorten the timeframe from imaging diagnosis to interventional treatment.
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Mostafa et al. (2024) conducted an observational in Suspected acute myocardial infarction based on incidental perfusion defects on emergency CT (n=22). Emergency computed tomography (CT) vs. Invasive coronary angiography (ICA) was evaluated on Correlation between hypoperfused segments on CT imaging and the corresponding vascular territory upon ICA (ρ = 0.73, p=< 0.001). Myocardial hypoperfusion detected on emergency CT imaging showed a strong correlation (ρ = 0.73) with corresponding vascular territories upon invasive coronary angiography.
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