What does this research mean for the field?

Having 5 to 6 healthy cardiovascular factors significantly reduces the risk of cardiovascular mortality (HR 0.35) compared to the average population risk, with the protective effect being particularly significant in men. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

December 5, 2014PLoS ONEOpen Access

Health Factors and Risk of All-Cause, Cardiovascular, and Coronary Heart Disease Mortality: Findings from the MONICA and HAPIEE Studies in Lithuania

Q: What is the clinical evidence from this study?

Study design: Cohort. Population: Cardiovascular disease (n=9209). Intervention: 5-6 healthy cardiovascular factors vs. Average risk in the whole population. Primary outcome: Cardiovascular mortality (HR 0.35, 95% CI 0.15-0.83, p=0.017).

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Key result

Having 5 to 6 healthy cardiovascular factors significantly reduced the risk of cardiovascular mortality (HR 0.35) compared to the average risk in the whole population.

Why the study?

Does having a greater number of healthy cardiovascular risk factors reduce all-cause, CVD, and CHD mortality in an urban population?

Population

9,209 men and women aged 45-64 from Kaunas, Lithuania

Comparison

Having 5-6 healthy cardiovascular risk factors vs Average risk in the whole population or high…

Design

Cohort

Authors

ATAbdonas Tamošiūnas DLDalia Lukšienė MBMiglė Bacevičienė

Discussion

Member takes

Overview

Reinforces the profound survival benefit of cumulative lifestyle optimization; leaves open whether targeted interventions can prospectively.

Study Design

Type

Cohort (n=9,209)

Multicenter

Structured PICO

Does having a greater number of healthy cardiovascular risk factors reduce all-cause, CVD, and CHD mortality in an urban population?

Population

9,209 men and women aged 45-64 from Kaunas, Lithuania (7,648 free from coronary heart disease and stroke at baseline)

Intervention

Having 5-6 healthy cardiovascular risk factors (non-smoking, normal weight, normal arterial blood pressure, normal level of total serum cholesterol, normal physical activity, and normal level of fasting glucose)

Comparator

Average risk in the whole population or high levels of risk factors

Outcome

All-cause, cardiovascular (CVD), and coronary heart disease (CHD) mortalityhard clinical

Main Result

Effect estimate: HR 0.35 (95% CI 0.15-0.83)

p-value: p=0.017

A greater number of healthy cardiovascular risk factors is associated with a significantly lower risk of CVD mortality, particularly among men.

Limitations

Only one assessment of the included healthy cardiovascular factors, leading to potential exposure misclassification
Physical activity and nutritional habits were assessed using different questionnaires across surveys
Capillary blood glucose was measured, which is less reliable and less sensitive
Included random population samples in one urban setting rather than national samples

Cite This Study

Tamošiūnas et al. (2014) conducted a cohort in Cardiovascular disease (n=9,209). 5-6 healthy cardiovascular factors vs. Average risk in the whole population was evaluated on Cardiovascular mortality (HR 0.35, 95% CI 0.15-0.83, p=0.017). Having 5 to 6 healthy cardiovascular factors significantly reduced the risk of cardiovascular mortality (HR 0.35) compared to the average risk in the whole population.

synapsesocial.com/papers/6a12ce2d06ed52b5c2c09308 https://doi.org/10.1371/journal.pone.0114283

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December 5, 2014PLoS ONEOpen Access

Health Factors and Risk of All-Cause, Cardiovascular, and Coronary Heart Disease Mortality: Findings from the MONICA and HAPIEE Studies in Lithuania

View Full Paper

Ask AI

Bookmark

Key result

Having 5 to 6 healthy cardiovascular factors significantly reduced the risk of cardiovascular mortality (HR 0.35) compared to the average risk in the whole population.

Why the study?

Does having a greater number of healthy cardiovascular risk factors reduce all-cause, CVD, and CHD mortality in an urban population?

Population

9,209 men and women aged 45-64 from Kaunas, Lithuania

Comparison

Having 5-6 healthy cardiovascular risk factors vs Average risk in the whole population or high…

Design

Cohort

Authors

ATAbdonas Tamošiūnas DLDalia Lukšienė MBMiglė Bacevičienė

Discussion

Member takes

Overview

Reinforces the profound survival benefit of cumulative lifestyle optimization; leaves open whether targeted interventions can prospectively.

Study Design

Type

Cohort (n=9,209)

Multicenter

Structured PICO

Does having a greater number of healthy cardiovascular risk factors reduce all-cause, CVD, and CHD mortality in an urban population?

Population

9,209 men and women aged 45-64 from Kaunas, Lithuania (7,648 free from coronary heart disease and stroke at baseline)

Intervention

Comparator

Average risk in the whole population or high levels of risk factors

Outcome

All-cause, cardiovascular (CVD), and coronary heart disease (CHD) mortalityhard clinical

Main Result

Effect estimate: HR 0.35 (95% CI 0.15-0.83)

p-value: p=0.017

A greater number of healthy cardiovascular risk factors is associated with a significantly lower risk of CVD mortality, particularly among men.

Limitations

Only one assessment of the included healthy cardiovascular factors, leading to potential exposure misclassification
Physical activity and nutritional habits were assessed using different questionnaires across surveys
Capillary blood glucose was measured, which is less reliable and less sensitive
Included random population samples in one urban setting rather than national samples

Cite This Study

synapsesocial.com/papers/6a12ce2d06ed52b5c2c09308 https://doi.org/10.1371/journal.pone.0114283

Also Consider

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