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August 31, 2012BMC Cardiovascular DisordersOpen Access

Trends in prevalence, awareness, treatment, and control of hypertension, and the risk of mortality among middle-aged Lithuanian urban population in 1983–2009

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Key result

Severe hypertension (blood pressure ≥180/110 mmHg) significantly increased the risk of overall mortality in middle-aged men (HR 2.19) and women (HR 1.95) compared to normal blood pressure.

Why the study?

Does higher blood pressure increase the risk of all-cause and cardiovascular mortality in a middle-aged Lithuanian urban population?

Population

4,709 men and women aged 45-64 years from the urban population of Kaunas, Lithuania, randomly selected from…

Design

Cohort

Follow-up

mean 11.8 ± 9.2 years

Authors

RRRegina RėklaitienėATAbdonas TamošiūnasDVDalia Virvičiūtė

Discussion

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Overview

Underscores BP monitoring in middle-aged adults; extends mortality associations to this population but remains observational and hypothesis-generating.

Key Points

  • This study aims to assess trends in prevalence, awareness, treatment, and control of hypertension and its associated mortality risk among middle-aged Lithuanians.
  • Evaluated time trends through MONICA health surveys conducted in 1983, 1986, 1992, and 2002
  • Randomly recruited 2,218 men and 2,491 women aged 45-64 years
  • Analyzed data using multivariate Cox proportional hazards regression
  • Hypertension prevalence in men remained stable at 52.1-58.7%, while in women it decreased from 61.0% to 51.0%.
  • Hypertension awareness increased significantly among men (45.0% to 64.4%) and women (47.7% to 72.3%).
  • There was a strong dose-response relationship between blood pressure levels and all-cause, CVD, CHD, and stroke mortality risk.

Study Design

Type

Cohort (n=4,709)

Multicenter

No

Structured PICO

Does higher blood pressure increase the risk of all-cause and cardiovascular mortality in a middle-aged Lithuanian urban population?

P
Population
4,709 men and women aged 45-64 years from the urban population of Kaunas, Lithuania, randomly selected from the population register across four surveys (1983, 1986, 1992, 2002).
C
Comparator
Normal blood pressure (<140/<90 mmHg) as reference category for mortality risk
O
Outcome
All-cause mortality, mortality from cardiovascular disease (CVD), coronary heart disease (CHD), and strokehard clinical

Main Result

Effect estimate: HR 2.19 (95% CI 1.75-2.74)

Limitations

  • Did not examine a national sample, included only a random sample of 45-64 year-old urban population
  • Limited to a single examination; individuals were classified as hypertensive based on measurements obtained on a single occasion
  • Hypertensive subjects without treatment at inclusion may have been treated later during follow-up
  • Did not examine a national sample, only an urban population aged 45-64 years
  • Limited to a single baseline examination for blood pressure classification
  • Treatment status may have changed during the follow-up period

Cite This Study

Rėklaitienė et al. (2012) conducted a cohort in Arterial hypertension (n=4,709). Severe hypertension (BP ≥180/110 mmHg) vs. Normal blood pressure (<140/90 mmHg) was evaluated on Overall mortality in men (HR 2.19, 95% CI 1.75-2.74). Severe hypertension (blood pressure ≥180/110 mmHg) significantly increased the risk of overall mortality in middle-aged men (HR 2.19) and women (HR 1.95) compared to normal blood pressure.

synapsesocial.com/papers/6a1275abea48cb855a34e2b2https://doi.org/10.1186/1471-2261-12-68
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

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