Key result
Apparent resistant hypertension is linked to ~73% lower treatment success than treated hypertension in middle-aged men.
Why the study?
Hypertension is a significant cardiovascular disease risk factor, and a subset of patients has apparently resistant hypertension with inadequately controlled blood pressure despite treatment.
Do middle-aged men with apparent resistant hypertension have a higher prevalence of cardiovascular risk factors compared to those with treated hypertension?
Population
52,012 men in the Lithuanian High Cardiovascular Risk Programme (LitHiR) between 2009 and 2019
Comparison
Treated hypertension vs apparent resistant hypertension
Design
Comparative observational study
Authors
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Supports intensified risk assessment in middle-aged men with apparent resistant hypertension; leaves open whether targeting dyslipidemia and metabolic syndrome improves control.
Observational (n=52,012)
Do middle-aged men with apparent resistant hypertension have a higher prevalence of cardiovascular risk factors compared to those with treated hypertension?
Absolute Event Rate: 7.57% vs 28.4%
p-value: p=<0.001
Middle-aged men with apparent resistant hypertension have a significantly higher burden of cardiovascular risk factors and lower treatment success rates compared to those with treated hypertension.
Šileikienė et al. (2025) conducted an observational in Hypertension and apparent resistant hypertension (n=52,012). Apparent resistant hypertension (aRHTN) vs. Treated hypertension (HTN) was evaluated on Treatment success (p=<0.001). Apparent resistant hypertension in middle-aged men was associated with significantly lower treatment success compared to treated hypertension (7.57% vs. 28.4%, p<0.001).
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