Effect of heart rate on the canine end-systolic pressure-volume relationship.
Why the study?
Does increasing heart rate affect the ventricular end-systolic pressure-volume relationship in isolated canine hearts?
Population
Isolated, ejecting canine heart preparation perfused at a constant coronary arterial pressure (n=6 hearts)
Comparison
Changing heart rate from 60 to 200 beats/min in… vs Baseline heart rate and other heart rate steps
Design
Preclinical
Authors
Discussion
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Member takes
Implication
Heart rate may confound ESPVR-based contractility assessment; challenges prior insensitivity claims but leaves open clinical translation.
Structured PICO
Does increasing heart rate affect the ventricular end-systolic pressure-volume relationship in isolated canine hearts?
P
Population
Isolated, ejecting canine heart preparation perfused at a constant coronary arterial pressure (n=6 hearts)
I
Intervention
Changing heart rate from 60 to 200 beats/min in steps of 20 beats/min
C
Comparator
Baseline heart rate (60 beats/min) and other heart rate steps
O
Outcome
Slope of the end-systolic pressure-volume relationship (Ees) and volume axis intercept (V0)surrogate
The ventricular end-systolic pressure-volume relationship is dependent on heart rate, with increases in heart rate up to 120 beats/min acting similarly to positive inotropic interventions.
Cite This Study
Maughan et al. (1985) studied this question.