Why the study?
Does electrical stimulation of an afferent nerve from muscle affect left ventricular performance in open-chest dogs?
Does electrical stimulation of an afferent nerve from muscle affect left ventricular performance in open-chest dogs?
Activation of high-threshold afferent muscle fibers increases left ventricular contractility, suggesting a physiological mechanism for enhanced cardiac performance during muscular exercise.
Supports reflex-mediated LV performance gains during exercise in dogs; leaves open human translation and clinical relevance.
The effect on left ventricular performance of electrical stimulation of the cut central end of the quadriceps nerve was studied in open-chest dogs. Stimulation of the nerve at 2 to 4 times threshold for the flexion reflex, which presumably activated intermediate-sized afferent fibers, caused a decrease in heart rate and arterial pressure. Stimulation at 5 to 25 times threshold, which presumably activated small-sized, high-threshold afferent fibers, increased heart rate, arterial pressure, and cardiac output. When heart rate, arterial pressure, and cardiac output were controlled, activation of high-threshold afferent fibers caused a significant increase in the maximal rate of pressure rise, stroke power, and mean rate of ejection of the left ventricle without an increase in the end-diastolic pressure. These same fibers may in some way be activated during muscular exercise and be partially responsible for the increase in left ventricular contractility that occurs during that time.
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Mitchell et al. (1968) studied this question.
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