Why the study?
Does enhanced ventricular contractility alter the left ventricular pressure response to vagus nerve stimulation in a canine model?
Population
Canine isovolumetric left ventricle preparation
Comparison
Vagus nerve stimulation during enhanced… vs Vagus nerve stimulation under control conditions
Design
Preclinical
Authors
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Indicates sympathetic potentiation of vagal LV effects in canines; hypothesis-generating and leaves open human translation.
Does enhanced ventricular contractility alter the left ventricular pressure response to vagus nerve stimulation in a canine model?
The potentiation of vagal depressant effects during sympathetic stimulation indicates a specific adrenergic-cholinergic interaction in the heart.
Levy et al. (1969) studied this question.
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