Population
48 anesthetized, open-chest mongrel dogs with muscarinic and beta-adrenergic receptors blocked and…
Comparison
Vagal nerve stimulation at 20 Hz for 5 min, with… vs Baseline values prior to vagal nerve stimulation.
Design
Preclinical
Authors
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Does not support clinical vagal stimulation for RV function; leaves open VIP mediation in human autonomic therapies.
Vagal nerve stimulation increases right ventricular contraction, relaxation, and heart rate in dogs, an effect largely mediated by the release of vasoactive intestinal peptide.
Henning et al. (1996) studied this question.
Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context: