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May 1, 1990AJP Heart and Circulatory Physiology

Vagal stimulation attenuates sympathetic enhancement of left ventricular function

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Why the study?

Does vagal nerve stimulation attenuate the sympathetic enhancement of left ventricular function in anesthetized dogs?

Population

16 anesthetized dogs with ventricles paced at a fixed rate of 120 beats/min and constant systemic arterial…

Comparison

Vagal nerve stimulation combined with… vs Control level and sympathetic nerve stimulation…

Design

Preclinical

Authors

RHRobert J. HenningLouisiana State University Health Sciences Center ShreveportIKIrene KhalilMount Sinai HospitalMLMatthew N. LevyTechnion – Israel Institute of Technology

Discussion

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Implication

May attenuate sympathetic LV effects in dogs; leaves open translation to human autonomic therapies.

Structured PICO

Does vagal nerve stimulation attenuate the sympathetic enhancement of left ventricular function in anesthetized dogs?

P
Population
16 anesthetized dogs with ventricles paced at a fixed rate of 120 beats/min and constant systemic arterial pressure
I
Intervention
Vagal nerve stimulation (5 Hz) combined with sympathetic nerve stimulation (6 Hz)
C
Comparator
Control level (no stimulation) and sympathetic nerve stimulation alone (6 Hz)
O
Outcome
Maximum rates of left ventricular pressure rise (dP/dtmax) and fall (dP/dtmin)surrogate

Vagal stimulation significantly attenuates the sympathetic enhancement of left ventricular contraction and relaxation through a substantial antagonistic interaction.

Cite This Study

Henning et al. (1990) studied this question.

synapsesocial.com/papers/6a922cf65ab1441fe3c8019fhttps://doi.org/10.1152/ajpheart.1990.258.5.h1470
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Effect of Enhanced Contractility on the Left Ventricular Response to Vagus Nerve Stimulation in Dogs1969 · 63 citations
  2. 2Depression of Ventricular Contractility by Stimulation of the Vagus Nerves1965 · 171 citations
  3. 3Vagal stimulation decreases rate of left ventricular relaxation1989 · 10 citations
  4. 4Effect of vagal stimulation on the overflow of norepinephrine into the coronary sinus during cardiac sympathetic nerve stimulation in the dog.1976 · 175 citations
  5. 5Vagal nerve stimulation increases right ventricular contraction and relaxation and heart rate1996 · 22 citations