Why the study?
Does vagally released vasoactive intestinal peptide (VIP) modulate sinoatrial rate and promote tachycardia in isolated innervated rat hearts?
Population
Langendorff perfused rat hearts with the right vagus intact
Comparison
Right vagal stimulation with or without… vs Baseline/control conditions without VIP…
Design
Preclinical
Authors
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Supports VIP role in vagal rate modulation in rat hearts; leaves open human sinoatrial translation.
Does vagally released vasoactive intestinal peptide (VIP) modulate sinoatrial rate and promote tachycardia in isolated innervated rat hearts?
Endogenous release of vasoactive intestinal peptide during high-frequency vagal stimulation can limit bradycardia and promote vagotonic tachycardia in the isolated rat heart.
Shvilkin et al. (1994) studied this question.
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