December 1, 1990Circulation ResearchOpen Access

Vasoactive intestinal polypeptide facilitates atrioventricular nodal conduction and shortens atrial and ventricular refractory periods in conscious and anesthetized dogs.

View Full Paper

Ask AI

Bookmark

Structured PICO

Population

Dogs (n=8 conscious, chronically instrumented; n=3 anesthetized)

Intervention

Vasoactive intestinal polypeptide (VIP) (50 and 100 pmol/kg/min i.v. infusion, and bolus doses 10, 30, 100, 300 pmol/kg i.v.) after autonomic blockade

Comparator

Isoproterenol (ISO) (250 and 500 pmol/kg/min i.v. infusion, and bolus doses) and sodium nitroprusside

Outcome

Changes in heart rate, atrial-ventricular interval, atrial effective refractory period, ventricular effective refractory period, and mean arterial pressuresurrogate

Vasoactive intestinal polypeptide directly alters cardiac electrical properties, facilitating AV nodal conduction and shortening refractory periods independent of beta-adrenergic receptors.

Authors

DRDean F. RigelNovartis (United States)DLDavid A. LathropTexas Cardiac Arrhythmia

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

Animal data extend VIP's role in cardiac conduction; human studies needed before clinical relevance.

Cite This Study

Rigel et al. (1990) studied this question.

synapsesocial.com/papers/6a8bd6b13fd21775a533bee0 https://doi.org/10.1161/01.res.67.6.1323

View Full Paper

Ask AI

Bookmark

Vasoactive intestinal polypeptide facilitates atrioventricular nodal conduction and shortens atrial and ventricular refractory periods in conscious and anesthetized dogs.

Structured PICO

Discussion

Implication

Cite This Study

Vasoactive intestinal polypeptide facilitates atrioventricular nodal conduction and shortens atrial and ventricular refractory periods in conscious and anesthetized dogs.

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider