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September 18, 2013Circulation Arrhythmia and ElectrophysiologyOpen Access

Ionic Mechanisms Underlying the Effects of Vasoactive Intestinal Polypeptide on Canine Atrial Myocardium

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Population

Canine atrial cardiomyocytes and isolated canine left atria

Design

Preclinical

Authors

YXYutao XiValve (United States)GWGeru WuTexas Medical CenterTATomohiko AiElectrophysiology

Discussion

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Implication

VIP effects on canine atrial electrophysiology do not inform patient care; leaves open its role in human AF.

Structured PICO

P
Population
Canine atrial cardiomyocytes and isolated canine left atria
I
Intervention
Vasoactive intestinal polypeptide (VIP)
O
Outcome
Effects on transmembrane ion channels, action potential durations (APDs), and conduction velocitysurrogate

VIP alters multiple ion channels in canine atrial myocardium, leading to shortened action potential duration, increased spatial heterogeneity, and slowed conduction velocity, which may promote atrial arrhythmias.

Cite This Study

Xi et al. (2013) studied this question.

synapsesocial.com/papers/6a6fbd64febe604dd7089717https://doi.org/10.1161/circep.113.000518

Topics

Atrial fibrillationPersistent AF management
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Transient outward and delayed rectifier currents in canine atrium: properties and role of isolation methods1996 · 156 citations
  2. 2Delayed rectifier K+ current in rabbit atrial myocytes1995 · 32 citations
  3. 3Vagally induced block and delayed conduction as a mechanism for circus movement tachycardia in frog atria.1989 · 27 citations
  4. 4Functional properties of K+ currents in adult mouse ventricular myocytes2004 · 129 citations
  5. 5Dominant-Negative Control of cAMP-Dependent I Ks Upregulation in Human Long-QT Syndrome Type 12011 · 67 citations