Why the study?
Does repetitive vagal stimulation affect heart rate and cardiac vasoactive intestinal polypeptide efflux in dogs?
Population
Dogs anesthetized with alpha-chloralose and isolated, perfused right atrial preparations
Comparison
Successive 2-min periods of intense vagal… vs Response to vasoactive intestinal polypeptide…
Design
Preclinical
Follow-up
84 min
Authors
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Repetitive vagal stimulation may attenuate tachycardia via VIP depletion in dogs; leaves open its role in human autonomic responses.
Does repetitive vagal stimulation affect heart rate and cardiac vasoactive intestinal polypeptide efflux in dogs?
Repetitive vagal stimulation diminishes vagally induced tachycardia, likely due to reduced neuronal release of vasoactive intestinal polypeptide (VIP).
Hill et al. (1995) studied this question.
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