Population
Isolated innervated rat atrium (n=12 rats for vagal stimulation, n=5 rats for VIP experiments)
Comparison
Vagal stimulation before and after atropine in… vs Baseline/control conditions before atropine or…
Design
Preclinical
Authors
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No vagal or VIP tachycardia in isolated rat atrium; leaves open mechanisms in intact models or other species.
This in vitro study demonstrates that vagal tachycardia is absent and vasoactive intestinal polypeptide does not induce significant tachycardia in the isolated rat atrium.
Hogan et al. (2005) studied this question.
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