Why the study?
Does exogenous and endogenous vasoactive intestinal peptide improve left ventricular performance in anesthetized dogs?
Population
8 anesthetized open-chest dogs instrumented to measure LV pressure and volume, pretreated with atropine and…
Comparison
Exogenous intravenous vasoactive intestinal… vs Steady state (baseline)
Design
Preclinical
Authors
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Animal data support VIP in LV performance; leaves open translation to human HF therapy.
Does exogenous and endogenous vasoactive intestinal peptide improve left ventricular performance in anesthetized dogs?
Both exogenous and endogenously released vasoactive intestinal peptide enhance left ventricular contractile function and relaxation in an anesthetized dog model.
Xenopoulos et al. (1994) studied this question.
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