July 1, 1966Circulation Research

Sympathetic and Parasympathetic Interactions upon the Left Ventricle of the Dog

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Population

Canine isovolumetric left ventricle preparations

Design

Preclinical

Authors

MLMatthew N. LevyTechnion – Israel Institute of Technology MNMANUEL L. NGRainbow Babies & Children's Hospital PMPaul MartinUniversity of Manchester

Discussion

Member takes

Implication

Vagal effects on LVSP via sympathetic antagonism warrant exploration in autonomic therapies; leaves open translation from animal models to clinical use.

Structured PICO

Population

Canine isovolumetric left ventricle preparations

Intervention

Stimulation of the cardiac end of a cut cervical vagus nerve

Outcome

Change in left ventricular systolic pressure (LVSP)surrogate

Vagal stimulation reduces left ventricular systolic pressure in part by antagonizing prevailing sympathetic nervous activity.

Cite This Study

Levy et al. (1966) studied this question.

synapsesocial.com/papers/6a7395a91aa2fc9e78fb6ae8 https://doi.org/10.1161/01.res.19.1.5

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Implication

Vagal effects on LVSP via sympathetic antagonism warrant exploration in autonomic therapies; leaves open translation from animal models to clinical use.

Sympathetic and Parasympathetic Interactions upon the Left Ventricle of the Dog

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Sympathetic and Parasympathetic Interactions upon the Left Ventricle of the Dog

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider