Key result
Hypertension has a global prevalence of up to 30% and is a major risk factor for cardiovascular morbidity and mortality, driving research into its pathogenic mechanisms.
This review summarizes the current understanding of the pathogenic mechanisms of hypertension and its complications.
Hypertension remains a leading CV risk; leaves open targeted mechanistic therapies pending further validation.
Hypertension, with a prevalence of up to 30% throughout the world, is increasing in incidence in more affluent and aging populations. Because it is totally asymptomatic, it has been named the silent killer, as it is the major contributor-or risk factor-to cardiovascular morbidity and mortality. A large body of research over the past several decades has been devoted to investigating the causes and mechanisms of hypertension. Although the causes-genetic and environmental-remain obscure, much progress has been made in elucidating some of the pathogenic mechanisms causing hypertension, as well as its common complications, ie. ischemic heart disease, stroke and renal failure. The ultimate goal of this research is to inhibit these mechanisms and thus prevent or reverse the hypertensive complications.
No takes yet. Share an insight, caveat, or question.
Haralambos Gavras (2009) conducted a review in Hypertension. Hypertension has a global prevalence of up to 30% and is a major risk factor for cardiovascular morbidity and mortality, driving research into its pathogenic mechanisms.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: