Key result
Plasma renin activity independently predicted all-cause mortality and heart failure readmission (HR 1.205) and provided incremental predictive value to NT-proBNP in patients with acute heart failure.
Why the study?
The association between NT-proBNP and plasma renin activity (PRA), as well as the incremental prognostic value of PRA added to NT-proBNP in acute heart failure, has not been fully investigated.
Does plasma renin activity (PRA) provide incremental predictive value to NT-proBNP for predicting long-term prognosis in patients with acute heart failure?
Observational (n=396)
No
Does plasma renin activity (PRA) provide incremental predictive value to NT-proBNP for predicting long-term prognosis in patients with acute heart failure?
Plasma renin activity (PRA) provides incremental prognostic value beyond NT-proBNP for predicting mortality and readmission in patients with acute heart failure.
BACKGROUND: The association of N-terminal pro-B type natriuretic peptide (NT-proBNP) and plasma renin activity (PRA) for the prognosis of the patients with acute heart failure (HF) has not been fully investigated. This study aimed to determine the association between NT-proBNP and PRA and to investigate the incremental value of PRA to NT-proBNP for predicting long term prognosis in patients with acute HF. METHODS: Three hundred and ninety-six patients (mean age, 64.7 ± 15.9 years; 46.5% female) presenting with acute HF were enrolled between December 2004 and July 2013. Patients with newly diagnosed HF as well as patients with acute exacerbated chronic HF were included. The prognosis was assessed with the composite event of all-cause mortality and readmission for HF during a 2-year follow-up period. CONCLUSION: PRA could provide incremental predictive value to NT-proBNP for predicting long term prognosis in patients with acute HF.
No takes yet. Share an insight, caveat, or question.
Park et al. (2020) conducted an observational in Acute heart failure (n=396). Plasma Renin Activity (PRA) was evaluated on Composite of all-cause mortality and readmission for heart failure (HR 1.205, 95% CI 1.052-1.380, p=0.007). Plasma renin activity independently predicted all-cause mortality and heart failure readmission (HR 1.205) and provided incremental predictive value to NT-proBNP in patients with acute heart failure.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: