Key result
Septal myectomy in patients with HOCM significantly reduced LV outflow gradient (63.13 to 9.96 mmHg, P<0.0001) and normalized high circumferential strain (-28.47 to -18.26, P<0.05).
Why the study?
Although septal myectomy relieves LV outflow tract pressure gradient in HOCM, it was unknown whether functional improvement is associated with improved myocardial mechanics.
Does septal myectomy improve left ventricular mechanics in patients with hypertrophic obstructive cardiomyopathy?
Observational (n=15)
Does septal myectomy improve left ventricular mechanics in patients with hypertrophic obstructive cardiomyopathy?
Absolute Event Rate: -18.26% vs -28.47%
p-value: p=<0.05
In patients with HOCM, septal myectomy significantly reduces LV outflow gradient and normalizes circumferential strain and LV twist, suggesting symptomatic improvement is primarily driven by improved predictors of diastolic function.
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Supports myectomy for LV mechanics in HOCM; leaves open causal outcome confirmation in RCTs.
Kareem et al. (2019) conducted an observational in hypertrophic obstructive cardiomyopathy (HOCM) (n=15). septal myectomy vs. baseline (pre-myectomy) was evaluated on Circumferential strain (p=<0.05). Septal myectomy in patients with HOCM significantly reduced LV outflow gradient (63.13 to 9.96 mmHg, P<0.0001) and normalized high circumferential strain (-28.47 to -18.26, P<0.05).
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