Key result
Septal myectomy in HCM is linked to ~25% improved LA strain but worsened LV GLS.
Why the study?
LA and LV mechanical function are prognostic in HCM, but whether myocardial mechanical function can be improved by septal reduction therapy in symptomatic obstructive HCM remains to be explored.
Does septal myectomy improve left atrial and left ventricular mechanical function in patients with symptomatic obstructive hypertrophic cardiomyopathy?
Observational (n=44)
Does septal myectomy improve left atrial and left ventricular mechanical function in patients with symptomatic obstructive hypertrophic cardiomyopathy?
Absolute Event Rate: 30.5% vs 24.4%
p-value: p=0.004
Surgical septal myectomy for symptomatic obstructive HCM significantly reduces LA volume and improves LA mechanical function, but is associated with a deterioration in LV global longitudinal strain at 1 year.
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May support myectomy for LA function in obstructive HCM; leaves open net effects of worsened LV strain on outcomes.
Ha et al. (2023) conducted an observational in Symptomatic obstructive hypertrophic cardiomyopathy (n=44). Septal myectomy vs. Baseline (pre-surgery) was evaluated on LA strain (p=0.004). Septal myectomy in symptomatic obstructive HCM significantly improved LA strain (24.4% to 30.5%, P=0.004) but worsened LV global longitudinal strain (-12.6% to -11.6%, P=0.033).
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