March 1, 2016Echocardiography
Impact of Septal Reduction on Left Atrial Size and Diastole in Hypertrophic Cardiomyopathy
Why the study?
Does septal reduction reduce left atrial size and improve diastolic function in patients with hypertrophic cardiomyopathy?
Population
40 patients with hypertrophic cardiomyopathy (HCM), mean age 50 ± 14, 64% male.
Comparison
Septal reduction vs Pre-procedure baseline
Design
Cohort
Follow-up
1 year
Authors
Discussion
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Implication
Septal reduction was associated with reduced LA volume without diastolic gains in HCM; leaves open effects on symptoms or outcomes.
Structured PICO
Does septal reduction reduce left atrial size and improve diastolic function in patients with hypertrophic cardiomyopathy?
P
Population
40 patients with hypertrophic cardiomyopathy (HCM), mean age 50 ± 14, 64% male.
I
Intervention
Septal reduction (myectomy [n=31] or alcohol septal ablation [n=9])
C
Comparator
Pre-procedure baseline
O
Outcome
Left atrial (LA) size and diastolic function at 1 year follow-upsurrogate
Septal reduction in hypertrophic cardiomyopathy significantly reduces left atrial volume index but does not improve echocardiographic parameters of diastolic function at 1 year.
Cite This Study
Finocchiaro et al. (2016) studied this question.