Key result
Decreased SaO2 before and during hemodialysis predicts intradialytic SBP increases.
Why the study?
Intradialytic hypertension carries an increased risk for hospitalizations and mortality, but its pathogenesis is not well understood, and hypoxemia is thought to stimulate blood pressure elevation.
Does decreased arterial oxygen saturation correlate with intradialytic hypertension in regular hemodialysis patients?
Observational (n=75)
Does decreased arterial oxygen saturation correlate with intradialytic hypertension in regular hemodialysis patients?
p-value: p=<0.001
Decreased arterial oxygen saturation before and during hemodialysis is strongly associated with intradialytic hypertension and may serve as a predictor for systolic blood pressure elevation.
SaO2 monitoring may flag intradialytic hypertension risk; hypothesis-generating and requires prospective validation before practice change.
Background Patients with IDHTN have an increased risk for hospitalizations and mortality. The pathogenesis of IDHTN is not well understood. Hypoxemia is thought to stimulate the blood pressure (BP) elevation. The aim of this work was to study the changes of the arterial oxygen saturation (SaO 2 ) during hemodialysis (HD) and their relations to intradialytic hypertension (IDHTN). Patients and methods This is a prospective observational study that analyzed SaO 2 and BP changes during HD sessions in 75 regular HD patients over 6 months. Patients were divided into two groups: group A included patients without intradialytic hypertension (non-IDHTN) and group B included patients with persistent IDHTN group. Results Group B patients had significantly lower predialysis, intradialytic, and postdialysis SaO 2 levels compared with group A ( P <0.001). Group B patients also showed a significant drop in intradialytic SaO 2 compared to group A ( P <0.001). There were significant negative correlations between the predialysis, intradialytic, and postdialysis SaO 2 and intradialytic systolic blood pressure elevation ( P <0.001). It was found that the reduction of the predialysis and intradialytic SaO 2 less than 92.5 and 90.5%, respectively, could be predictors of intradialytic systolic blood pressure increase ( P <0.001). Conclusion Decreased SaO 2 before and during HD sessions may be involved in the induction of IDHTN.
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Khamis et al. (2021) conducted an observational in Intradialytic hypertension in hemodialysis patients (n=75). Arterial oxygen saturation (SaO2) levels vs. Patients without intradialytic hypertension was evaluated on Relation between SaO2 levels and intradialytic systolic blood pressure elevation (p=<0.001). Decreased arterial oxygen saturation before (<92.5%) and during (<90.5%) hemodialysis sessions significantly predicted intradialytic systolic blood pressure increases (P<0.001).
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