Key result
Pharmaco-mechanic antithrombotic strategies for STEMI reperfusion must be individualized based on patient risk profile, as there is no single optimal evidence-based approach for all patients.
A tailored combination of modern antithrombotic pharmacotherapy and mechanical reperfusion techniques is essential for optimizing outcomes in STEMI patients.
Supports individualized antithrombotic strategies in STEMI; leaves open optimal regimen identification in prospective trials.
Primary percutaneous coronary intervention is the best treatment of patients with ST elevation myocardial infarction (STEMI). When managing a STEMI patient, our approach must be rapid and aggresive in order to interrupt the pathological process of thrombus formation and stabilization. The therapy must be initiated prior to angiography (pretreatment), continued during the procedure (periprocedural), recovery phase (in-hospital), and follow-up. The treatment strategies resulting in thrombus dissolution/extraction have focused on optimization of both pharmacological and interventional therapies. At present, there is no optimal evidence-based approach to all patients with STEMI, and the treatment of these patients needs to be modified with respect to the risk profile, availability of medical resources, and our experience. In this review, we summarize current pharmacological and interventional strategies used in the setting of STEMI and discuss potential benefits of novel dosing regimens and combinations of drugs and techniques.
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Kala et al. (2013) conducted a review in ST-Elevation Acute Myocardial Infarction (STEMI). Pharmaco-mechanic antithrombotic strategies was evaluated. Pharmaco-mechanic antithrombotic strategies for STEMI reperfusion must be individualized based on patient risk profile, as there is no single optimal evidence-based approach for all patients.
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