Key result
Left ventricular diastolic dysfunction severity was strongly correlated with indexed maximum left atrial volume (rs = 0.79, P < 0.01), which predicted dysfunction with 97% sensitivity.
Why the study?
How does left ventricular diastolic dysfunction impact left atrial volume and function in patients with normal LV systolic function?
Population
83 patients with normal LV systolic function
Design
Cross-sectional
Authors
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May aid noninvasive grading of diastolic dysfunction; hypothesis-generating and requires prospective validation before clinical adoption.
Observational (n=83)
How does left ventricular diastolic dysfunction impact left atrial volume and function in patients with normal LV systolic function?
Effect estimate: rs = 0.79
p-value: p=< 0.01
Left atrial volume and function reflect the severity of LV diastolic dysfunction, with initial compensatory augmentation of active atrial contraction followed by mechanical failure at higher grades of dysfunction.
Teo et al. (2009) conducted an observational in Left ventricular diastolic dysfunction (n=83). Left ventricular diastolic dysfunction vs. Normal controls was evaluated on Association between indexed maximum left atrial volume and left ventricular diastolic function grade (rs = 0.79, p=< 0.01). Left ventricular diastolic dysfunction severity was strongly correlated with indexed maximum left atrial volume (rs = 0.79, P < 0.01), which predicted dysfunction with 97% sensitivity.
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