What question did this study set out to answer?

To determine the relationship between left atrial remodeling and left ventricular diastolic dysfunction in hypertensive patients with preserved ejection fraction.

March 24, 2013Acta Physiologica Hungarica

Left atrium systolic and diastolic function assessment in hypertensive patients with preserved ejection fraction

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Why the study?

Does echocardiographic assessment of left atrium volumes correlate with left ventricle diastolic dysfunction in hypertensive patients with preserved ejection fraction?

Population

192 subjects total: 96 hypertensive patients with preserved systolic function and 96 healthy control subjects.

Comparison

Echocardiographic measurement of left atrium… vs Healthy control subjects.

Design

Cohort

Authors

LALucia Agoşton-ColdeaCardiac Imaging SLSilvia LupuUniversitatea de Medicină, Farmacie, Științe și Tehnologie „George Emil Palade” din Târgu Mureș SHSergiu HiceaIuliu Hațieganu University of Medicine and Pharmacy

Discussion

Member takes

Implication

Indexed LA volume may identify early diastolic dysfunction in hypertensives with preserved EF; hypothesis-generating and should not yet change practice.

Key Points

To determine the relationship between left atrial remodeling and left ventricular diastolic dysfunction in hypertensive patients with preserved ejection fraction.
Conducted a prospective study analyzing 96 hypertensive patients (mean age 48.75 ± 5.01 years; 50 men) and 96 healthy controls (mean age 48.17 ± 8.52 years; 56 men).
Assessed left atrial volumes across reservoir, conduit, and pump phases along with standard left ventricular filling indices using transthoracic echocardiography.
Indexed left atrial volume was significantly higher in hypertensive patients than in controls (30.87 ± 6.38 mL/m² vs. 21.72 ± 2.52 mL/m²) and strongly correlated with left ventricular diastolic function (p < 0.0001).
Compared to controls, patients with mild diastolic dysfunction had reduced corrected passive emptying volume (p < 0.0001) and increased active emptying volume (p = 0.001), maintaining similar total emptying volume (p < 0.001).
Patients with moderate diastolic dysfunction exhibited lower active emptying volumes but higher passive and total emptying volumes relative to healthy controls and mild dysfunction patients.

Structured PICO

Does echocardiographic assessment of left atrium volumes correlate with left ventricle diastolic dysfunction in hypertensive patients with preserved ejection fraction?

Population

192 subjects total: 96 hypertensive patients with preserved systolic function (mean age 48.75 ± 5.01 years, 50 men) and 96 healthy control subjects (mean age 48.17 ± 8.52 years, 56 men).

Intervention

Echocardiographic measurement of left atrium volumes during the reservoir, conduit, and pump phases.

Comparator

Healthy control subjects.

Outcome

Relationship between left atrium remodeling (indexed volumes) and left ventricle diastolic dysfunction.surrogate

Left atrium indexed volume evaluation during different cardiac phases is a useful surrogate marker for early diastolic dysfunction in hypertensive patients with preserved ejection fraction.

Cite This Study

Agoşton-Coldea et al. (2013) studied this question.

synapsesocial.com/papers/6a8d107cc9fcfbd7f7906785 https://doi.org/10.1556/aphysiol.100.2013.002

Topics

Hypertension management Echocardiography

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Implication

Indexed LA volume may identify early diastolic dysfunction in hypertensives with preserved EF; hypothesis-generating and should not yet change practice.

Left atrium systolic and diastolic function assessment in hypertensive patients with preserved ejection fraction

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Topics

Left atrium systolic and diastolic function assessment in hypertensive patients with preserved ejection fraction

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Topics

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