Key result
Baroreflex activation therapy produced a significant reduction in N-terminal pro-brain natriuretic peptide (p < 0.02) and a trend toward fewer in-hospital days for heart failure.
Why the study?
Does baroreflex activation therapy reduce NT-proBNP and hospitalizations in NYHA Class III heart failure patients?
RCT (n=146)
parallel
Yes
Does baroreflex activation therapy reduce NT-proBNP and hospitalizations in NYHA Class III heart failure patients?
p-value: p=<0.02
Baroreflex activation therapy shows promise in reducing NT-proBNP and potentially decreasing heart failure hospitalizations in NYHA Class III patients.
May lower NT-proBNP in NYHA III HF; leaves open effect on hospitalizations.
Baroreflex activation therapy (BAT) results in centrally mediated reduction of sympathetic outflow and increased parasympathetic activity to the heart via a physiological reflex pathway. In a pilot study in 11 NYHA Class III heart failure (HF) patients, BAT produced a persistent significant reduction of sympathetic activity over 21 months follow-up and a dramatic decrease in the number and length of hospitalizations. In a multinational, prospective, randomized, parallel-controlled, clinical trial in 146 NYHA Class III HF patients, BAT produced a significant N-terminal pro-brain natriuretic peptide reduction (p < 0.02). This was associated with a trend toward fewer in-hospital days for HF. BAT might become a powerful tool to repair autonomic alterations due to HF at their origin and thus, profoundly affect the prognosis of advanced HF patients.
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Gronda et al. (2015) conducted an RCT in Heart failure (NYHA Class III) (n=146). Baroreflex activation therapy (BAT) was evaluated on N-terminal pro-brain natriuretic peptide reduction (p=<0.02). Baroreflex activation therapy produced a significant reduction in N-terminal pro-brain natriuretic peptide (p < 0.02) and a trend toward fewer in-hospital days for heart failure.
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