What does this research mean for the field?

Positive selection operates on 1-7% of codon positions in foot-and-mouth disease virus capsid genes, specifically at known antigenic sites, conferring a selective advantage for immune evasion. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.SUPPORTS_CONSENSUS.

January 1, 2001GeneticsOpen Access

Evidence for Positive Selection in Foot-and-Mouth Disease Virus Capsid Genes From Field Isolates

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Population

11 data sets of sequences obtained from six different serotypes of foot-and-mouth disease virus (FMDV)

Design

Preclinical

Authors

DHDaniel T. HaydonUniversity of Glasgow ABArmanda D. S. BastosUniversity of Pretoria NKNick J. KnowlesThe Pirbright Institute

Discussion

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Implication

Supports immune-driven selection in FMDV variants; extends monoclonal antibody data to natural sequence datasets.

Structured PICO

Population

11 data sets of sequences obtained from six different serotypes of foot-and-mouth disease virus (FMDV)

Intervention

Analysis of the ratio of nonsynonymous to synonymous substitutions

Outcome

Evidence of positive selection in capsid genes

The study provides evidence that arising antigenic variants of FMDV benefit from a selective advantage in their interaction with the immune system.

Cite This Study

Haydon et al. (2001) studied this question.

synapsesocial.com/papers/6a12ed02c031bb6829a78f05 https://doi.org/10.1093/genetics/157.1.7

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Evidence for Positive Selection in Foot-and-Mouth Disease Virus Capsid Genes From Field Isolates

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Evidence for Positive Selection in Foot-and-Mouth Disease Virus Capsid Genes From Field Isolates

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider