What does this research mean for the field?

A high degree of genetic variability in the hypervariable region 1 of the Hepatitis C virus E2/NS1 protein correlates with non-responsiveness to interferon therapy, whereas low variability is associated with a positive therapeutic response. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

September 1, 1992HepatologyOpen Access

The Degree of Variability in the Amino Terminal Region of the E2/Ns1 Protein of Hepatitis C Virus Correlates With Responsiveness to Interferon Therapy in Viremic Patients

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Why the study?

Does amino acid heterogeneity in the E2/NS1 viral protein correlate with responsiveness to interferon therapy in patients with chronic hepatitis C?

Population

6 patients with chronic hepatitis C virus infection treated with interferon-beta

Design

Case_series

Follow-up

6 months

Authors

SOShunichi OkadaYamato Municipal Hospital YAY. AkahaneObayashi (Japan)HSHiroshi SuzukiThe Wistar Institute

Discussion

Member takes

Implication

HCV E2/NS1 heterogeneity was associated with interferon nonresponse; hypothesis-generating and requires prospective validation before clinical use.

Structured PICO

Does amino acid heterogeneity in the E2/NS1 viral protein correlate with responsiveness to interferon therapy in patients with chronic hepatitis C?

Population

6 patients with chronic hepatitis C virus infection treated with interferon-beta (3 responders, 3 non-responders)

Intervention

Interferon-beta therapy

Outcome

Amino acid heterogeneity in the variable regions of the E2/NS1 viral proteinsurrogate

High variability in the E2/NS1 hypervariable region 1 of the hepatitis C virus is associated with nonresponsiveness to interferon therapy.

Cite This Study

Okada et al. (1992) studied this question.

synapsesocial.com/papers/6a12ed4e13ab6312a8c0bb17 https://doi.org/10.1002/hep.1840160302

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Implication

HCV E2/NS1 heterogeneity was associated with interferon nonresponse; hypothesis-generating and requires prospective validation before clinical use.

The Degree of Variability in the Amino Terminal Region of the E2/Ns1 Protein of Hepatitis C Virus Correlates With Responsiveness to Interferon Therapy in Viremic Patients

Discussion

Member takes

Implication

Structured PICO

Cite This Study

The Degree of Variability in the Amino Terminal Region of the E2/Ns1 Protein of Hepatitis C Virus Correlates With Responsiveness to Interferon Therapy in Viremic Patients

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider