January 9, 2004Journal of Medical Virology
Lack of clinical significance of variability in the internal ribosome entry site of hepatitis C virus
Why the study?
Does sequence variability in the HCV IRES region correlate with response to Interferon alpha 2b and Ribavirin therapy in patients with chronic hepatitis C?
Population
14 patients (7 women, 7 men) with chronic hepatitis C
Comparison
Interferon alpha 2b and Ribavirin vs Interferon alpha 2b and Ribavirin (non-responders)
Design
Cohort
Authors
Discussion
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Member takes
Implication
IRES variability was not associated with interferon-ribavirin response; leaves open whether other viral or host factors determine outcomes in chronic HCV.
Structured PICO
Does sequence variability in the HCV IRES region correlate with response to Interferon alpha 2b and Ribavirin therapy in patients with chronic hepatitis C?
P
Population
14 patients (7 women, 7 men) with chronic hepatitis C
I
Intervention
Interferon alpha 2b and Ribavirin (sustained responders)
C
Comparator
Interferon alpha 2b and Ribavirin (non-responders)
O
Outcome
Sequence variability in the Internal Ribosome Entry Site (IRES) region of HCVsurrogate
Variations observed in the HCV IRES region do not determine the response to antiviral therapy, though the integrity of this region is necessary for its activity.
Cite This Study
Thélu et al. (2004) studied this question.