Key result
GLS below -10 cm/s predicts a ~60% absolute increase in ventricular arrhythmias in reduced LVEF.
Why the study?
Many patients receiving primary prevention ICDs based on LVEF criteria do not experience events, highlighting the need for improved discrimination strategies.
Does global longitudinal strain assessed by 3D echocardiography predict the occurrence of ventricular arrhythmias in patients with heart failure and reduced LVEF?
Cohort (n=70)
Does global longitudinal strain assessed by 3D echocardiography predict the occurrence of ventricular arrhythmias in patients with heart failure and reduced LVEF?
Effect estimate: AUC 0.84
Absolute Event Rate: 69.2% vs 9.6%
p-value: p=<0.001
Global longitudinal strain assessed by 3D echocardiography is a strong predictor of ventricular arrhythmias in patients with reduced LVEF, potentially offering better risk stratification for ICD implantation than LVEF alone.
GLS below -10 cm/s was associated with ventricular arrhythmias in reduced LVEF; leaves open whether it refines ICD selection beyond LVEF.
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Nikoo et al. (2020) conducted a cohort in Ischaemic or dilated cardiomyopathy (n=70). Global longitudinal strain (GLS) below -10 cm/s vs. GLS above -10 cm/s was evaluated on Occurrence of ventricular arrhythmias (AUC 0.84, p=<0.001). Global longitudinal strain below -10 cm/s predicted ventricular arrhythmias in patients with reduced LVEF, occurring in 69.2% vs 9.6% of those with GLS above -10 cm/s (AUC 0.84, P<0.001).
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