Why the study?
Are IL-8 levels elevated in the synovial fluid of patients with rheumatoid arthritis and do they correlate with markers of disease severity?
Population
Patients with rheumatoid arthritis and other diseases accompanied by arthritic manifestations
Design
Cross-sectional
Authors
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IL-8 elevation in RA synovial fluid associates with inflammation; hypothesis-generating for its pathogenic role, needs prospective validation.
Are IL-8 levels elevated in the synovial fluid of patients with rheumatoid arthritis and do they correlate with markers of disease severity?
Elevated IL-8 levels in the synovial fluid of RA patients correlate with cellular influx and CRP, suggesting a pathogenic role for IL-8 in rheumatoid arthritis joint destruction.
Peichl et al. (1991) studied this question.
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