What question did this study set out to answer?

To examine developmental changes in the arborization and electrical excitability of layer 5 pyramidal neuron apical dendritic tufts during postnatal maturation.

August 1, 2000The Journal of PhysiologyOpen Access

Maturation of layer 5 neocortical pyramidal neurons: amplifying salient layer 1 and layer 4 inputs by Ca2+ action potentials in adult rat tuft dendrites

View Full Paper

Ask AI

Bookmark

Authors

JZJie ZhuOklahoma Medical Research Foundation

Discussion

Member takes

Implication

Neurodevelopmental study reveals progressive electrotonic isolation in rat layer 5 pyramidal neurons, indicating enhanced coincidence detection via dendritic calcium spikes.

Key Points

To examine developmental changes in the arborization and electrical excitability of layer 5 pyramidal neuron apical dendritic tufts during postnatal maturation.
Reconstructed biocytin-filled layer 5 pyramidal neurons from rats across postnatal days 2 to 56 (P2–P56).
Characterized dendritic and somatic excitability using square-pulse current injections and synaptic stimulations.
Apical trunk length increased with a greater than 5-fold increase in tuft-to-soma distance, accompanied by a drop in input resistance from >500 MΩ at P2 to <50 MΩ at P56.
Regenerative dendritic potentials shifted from short (~15 ms) Na+-dependent spikes at P2 to prolonged (~55 ms) Na+- and Ca2+-dependent complex potentials at P56.
Dendritic potentials remained tuft-restricted in juvenile animals (P14–P28) but frequently coupled with somatic action potentials in mature rats (>P42).

Cite This Study

Jie Zhu (2000) studied this question.

synapsesocial.com/papers/6a12fc6086514ddae6c0ecdf https://doi.org/10.1111/j.1469-7793.2000.00571.x

View Full Paper

Ask AI

Bookmark

Implication

Neurodevelopmental study reveals progressive electrotonic isolation in rat layer 5 pyramidal neurons, indicating enhanced coincidence detection via dendritic calcium spikes.

Maturation of layer 5 neocortical pyramidal neurons: amplifying salient layer 1 and layer 4 inputs by Ca2+ action potentials in adult rat tuft dendrites

Discussion

Member takes

Implication

Key Points

Cite This Study

Maturation of layer 5 neocortical pyramidal neurons: amplifying salient layer 1 and layer 4 inputs by Ca2+ action potentials in adult rat tuft dendrites

Discussion

Member takes

Implication

Key Points

Cite This Study

Also Consider

Also Consider