Why the study?
Does a family history of cardiovascular disease predict higher atherogenic lipid fractions in newborn infants?
Does a family history of cardiovascular disease predict higher atherogenic lipid fractions in newborn infants?
A family history of cardiovascular disease is associated with higher cord blood total and LDL cholesterol in male newborns, though its positive predictive value for high LDL-C is low.
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Low PPV limits newborn lipid screening utility; extends prior associations to cord blood in males but remains hypothesis-generating.
The levels of atherogenic lipid fractions are higher in children with a family history of ischemic cardiovascular disease (CD). This study was designed to examine this relationship in neonates. A total of 1276 newborns were investigated; 400 cord blood samples were collected for measurement of triglycerides (TG), total cholesterol (TC), LDL cholesterol (LDL-C) and HDL cholesterol (HDL-C); on day 4, 1200 capillary samples were taken for TC and TG measurements. Male newborns with a positive history of CD had higher concentrations of cord blood TC (P less than 0.04) and LDL-C (P less than 0.02). On day 4 this difference in TC was no longer detectable (LDL-C not determined). A coronary heart disease (CHD) risk factor family history is sensitive (0.87) in predicting high cord blood concentrations of LDL-C, the specificity being 0.46 and the positive predicting value 0.08.
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Bellù et al. (1992) studied this question.
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