Key result
Elevated maternal triglyceride levels during early pregnancy were significantly associated with an increased risk of congenital heart disease in offspring (OR 2.46).
Why the study?
It was unknown whether maternal blood lipid levels during early pregnancy are associated with the occurrence of congenital heart disease in offspring.
Are high maternal blood lipid levels during early pregnancy associated with an increased risk of congenital heart disease in offspring?
Case-Control (n=611)
No
Are high maternal blood lipid levels during early pregnancy associated with an increased risk of congenital heart disease in offspring?
Odds Ratio: 2.46 (95% CI 1.62–3.73)
p-value: p=<0.01
Elevated maternal lipid levels, specifically triglycerides, total/HDL cholesterol ratio, and apolipoprotein-A1, during early pregnancy are associated with an increased risk of congenital heart disease in offspring.
Maternal first-trimester lipids may flag offspring CHD risk; hypothesis-generating and requires prospective validation before any clinical use.
INTRODUCTION: This study aimed to investigate whether maternal blood lipid levels during early pregnancy are associated with the occurrence of congenital heart disease (CHD) in their offspring. MATERIAL AND METHODS: In this single-center case-control study, mothers of offspring with CHD (n = 230) and without CHD (n = 381) were included. Maternal lipid levels were determined on fasting blood samples taken in the first trimester. Relevant demographic and clinical data were extracted from the medical records. Maternal lipid profile was compared between the two groups, and regression analysis was performed to evaluate the association between lipid profile and CHD risk in offspring. RESULTS: Compared with the control group, levels of triglyceride, apolipoprotein-A1, and apolipoprotein-B in early pregnancy were significantly higher in the CHD group. Multivariate analyses showed that triglyceride (odds ratio [OR] 2.46, 95% CI 1.62-3.73, p < 0.01), total/high-density lipoprotein cholesterol (OR 2.10, 95% CI 1.07-4.13, p = 0.03), and apolipoprotein-A1 (OR 2.73, 95% CI 1.16-6.40, p = 0.02) were positively associated with CHD risk in offspring. CONCLUSIONS: Elevated maternal lipid profile was associated with increased risk of CHD in offspring.
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Cao et al. (2021) conducted a case-control in Congenital heart disease in offspring (n=611). Elevated maternal blood lipid levels (triglycerides) vs. Normal/lower maternal blood lipid levels was evaluated on Occurrence of congenital heart disease (CHD) in offspring (OR 2.46, 95% CI 1.62-3.73, p=<0.01). Elevated maternal triglyceride levels during early pregnancy were significantly associated with an increased risk of congenital heart disease in offspring (OR 2.46).
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