Key result
Maternal prescription of the anticlotting medication enoxaparin during the first trimester was associated with an increased risk of congenital heart disease in offspring (adjOR 3.22).
Why the study?
The study was conducted to investigate the role of maternal environmental factors in the aetiology of congenital heart disease.
Do maternal environmental factors such as pregestational diabetes, clotting disorders, and poor diet increase the risk of congenital heart disease in offspring?
Population
242 CHD cases and 966 controls
Comparison
Maternal environmental risk factors vs controls
Design
Population-based case-control study
Authors
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May signal elevated congenital heart disease risk with first-trimester enoxaparin; hypothesis-generating and should not yet change practice.
Case-Control (n=1,208)
Yes
Do maternal environmental factors such as pregestational diabetes, clotting disorders, and poor diet increase the risk of congenital heart disease in offspring?
Odds Ratio: 3.22 (95% CI 1.01–10.22)
Absolute Event Rate: 2.48% vs 0.83%
Maternal environmental factors, including pregestational diabetes, clotting disorders, and poor diet, are associated with an increased risk of congenital heart disease, highlighting potential targets for public health prevention.
Dolk et al. (2020) conducted a case-control in Congenital heart disease (n=1,208). Enoxaparin prescription vs. No enoxaparin prescription was evaluated on Congenital heart disease in offspring (adjOR 3.22, 95% CI 1.01-10.22). Maternal prescription of the anticlotting medication enoxaparin during the first trimester was associated with an increased risk of congenital heart disease in offspring (adjOR 3.22).
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