Why the study?
There is considerable heterogeneity across studies evaluating prenatal risk factors for congenital heart diseases.
Do maternal chronic diseases and parental exposures increase the risk of congenital heart diseases in offspring?
Population
170 studies quantifying nongenetic prenatal risk factors for CHDs published between 1989 and 2022
Comparison
Maternal chronic diseases and parental exposures vs non-exposure
Design
Systematic review and meta-analysis
Authors
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Maternal obesity, diabetes, smoking, and advanced age raise CHD risk; supports preconception counseling but leaves open causality and prevention trials.
Do maternal chronic diseases and parental exposures increase the risk of congenital heart diseases in offspring?
Maternal chronic diseases, particularly pregestational diabetes, and certain parental exposures are significantly associated with an increased risk of congenital heart diseases in offspring.
Khalilipalandi et al. (2024) studied this question.
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