Key result
Integration of functional electrophysiological information with structural and molecular changes is required to understand the mechanisms regulating normal and abnormal embryonic heart development.
Understanding the electrophysiology of the developing heart requires integrating novel functional assessment technologies with structural and molecular data.
Requires multimodal integration to elucidate embryonic cardiac mechanisms; leaves open optimal frameworks for congenital models.
Many diseases that result in dysfunction and dysmorphology of the heart originate in the embryo. However, the embryonic heart presents a challenging subject for study: especially challenging is its electrophysiology. Electrophysiological maturation of the embryonic heart without disturbing its physiological function requires the creation and deployment of novel technologies along with the use of classical techniques on a range of animal models. Each tool has its strengths and limitations and has contributed to making key discoveries to expand our understanding of cardiac development. Further progress in understanding the mechanisms that regulate the normal and abnormal development of the electrophysiology of the heart requires integration of this functional information with the more extensively elucidated structural and molecular changes.
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Watanabe et al. (2016) conducted a review in Embryonic heart electrophysiology. Integration of functional electrophysiological information with structural and molecular changes is required to understand the mechanisms regulating normal and abnormal embryonic heart development.
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