Key result
ADAMTS6 emerges as a critical protease in cardiovascular development and tissue-specific tumor functions.
Why the study?
ADAMTS6 was an orphan proteinase with relatively unknown expression and function, but emerging focus has uncovered its roles in development and disease.
This review highlights the emerging biological importance of ADAMTS6 in cardiovascular development and disease, identifying it as a potential target for therapeutic intervention.
ADAMTS6 merits exploration as a cardiovascular therapeutic target; leaves open clinical adoption pending prospective validation.
ADAMTS family members control mammalian development and disease, primarily through their function as proteases, by regulation of extracellular matrix composition. Until recently, ADAMTS6 was known as one of the orphan proteinases of the nineteen-member family with a relatively unknown expression pattern and function. Emerging focus on this enzyme has started to uncover these unknowns and revealed a vast importance and requirement of ADAMTS6 in cardiovascular and musculoskeletal development. In addition, ADAMTS6 has been linked to numerous disease settings including several types of cancer. This review summarizes the necessity of ADAMTS6 during development, its role in disease and requirement for essential prospective studies to fully realize its biological implications and potential for therapeutic intervention.
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Timothy J. Mead (2022) conducted a review in Cardiovascular, musculoskeletal, and cancer biology. ADAMTS6 was evaluated. ADAMTS6 is an emerging extracellular matrix protease that plays critical roles in cardiovascular and musculoskeletal development, and exhibits tissue-specific pro- and anti-tumor functions in various cancers.
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