Key result
ADAMTS7 is associated with CAD but its exact role in atherosclerosis remains undetermined.
Why the study?
The role of ADAMTS7 in the development of atherosclerosis is yet to be determined despite its strong association with coronary atherosclerotic disease.
This review highlights the emerging association between the ADAMTS7 metalloprotease and coronary atherosclerotic disease, emphasizing the need for further mechanistic studies.
Answers are grounded in this paper and cite their sources.
Preclinical ADAMTS7 data suggest vascular roles; leaves open human therapeutic validation in coronary disease.
Here, we provide a comprehensive review of current findings concerning the biochemistry and physiological functions of ADAMTS7, a metalloprotease that is known to interact with cartilage oligomeric matrix protein, progranulin, and alpha2-macroglobulin. Such broad substrate specificity and potentially diverse physiological functions make ADAMTS7 an interesting enzyme to study. ADAMTS7 has been shown to play a role in the pathogenesis of arthritis and disc disorders. More recently, the ADAMTS7 locus is identified to have a strong association with coronary atherosclerotic disease. However, the role of ADAMTS7 in the development of atherosclerosis is yet to be determined. The development of an easy and high throughput assay for ADAMTS7 activity and appropriate animal models will allow us to uncover the novel mechanisms of coronary arterial disease.
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Hayley A. Hanby (2013) conducted a review in Arthritis, disc disorders, and coronary atherosclerotic disease. ADAMTS7 was evaluated. ADAMTS7 is a metalloprotease associated with arthritis, disc disorders, and coronary atherosclerotic disease, though its exact role in atherosclerosis remains to be determined.
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