What is the clinical evidence from this study?

Study design: Observational. Population: Atrial fibrillation (n=73). Intervention: Circadian clock gene expression. Primary outcome: Correlation between AHRE burden, left atrial size, and circadian clock gene expression.

What does this research mean for the field?

Decreased expression of circadian clock genes (CRY1, NR1D1, RORA) and larger left atrial volume are significantly associated with a higher burden of atrial high-rate episodes in patients with atrial fibrillation. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.ESTABLISHES_NEW_DIRECTION.

January 7, 2021DiagnosticsOpen Access

Altered Expression of Circadian Clock Genes in Patients with Atrial Fibrillation Is Associated with Atrial High-Rate Episodes and Left Atrial Remodeling

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Key result

Decreased circadian clock gene expression and larger left atria correlate with higher AHRE burden in AF.

n=73

Why the study?

A prominent circadian variation occurs in AF attacks, but little is known about the expression of circadian clock genes in AF.

Is the altered expression of circadian clock genes associated with atrial high-rate episodes and left atrial remodeling in patients with atrial fibrillation?

Population

73 patients with pacemaker implantation (including 43 with AF)

Comparison

Persistent AF vs paroxysmal AF vs non-AF patients

Design

Prospective observational study

Authors

YCYung‐Lung ChenMemorial Hospital of South Bend JCJiin‐Haur ChuangChang Gung University HWHui‐Ting WangNingbo University

Discussion

Member takes

Implication

Hypothesis-generating for circadian roles in AF; should not yet change practice or guide interventions.

Study Design

Type

Observational (n=73)

Structured PICO

Is the altered expression of circadian clock genes associated with atrial high-rate episodes and left atrial remodeling in patients with atrial fibrillation?

Population

73 prospectively enrolled patients who had received pacemaker implantation, including 43 (59%) with clinically diagnosed atrial fibrillation (15 persistent, 28 paroxysmal).

Intervention

Measurement of expression levels of circadian clock genes in peripheral blood leukocytes

Comparator

Patients without atrial fibrillation or patients with different subtypes of atrial fibrillation (persistent vs. paroxysmal)

Outcome

Atrial high-rate episodes (AHREs) burden and left atrial (LA) size/remodelingsurrogate

Decreased expression of specific circadian clock genes in peripheral blood leukocytes is significantly associated with higher atrial high-rate episode burden and left atrial remodeling in patients with pacemakers.

Limitations

Underlying mechanism needs to be elucidated in further studies

Cite This Study

Chen et al. (2021) conducted an observational in Atrial fibrillation (n=73). Circadian clock gene expression was evaluated on Correlation between AHRE burden, left atrial size, and circadian clock gene expression. Decreased expression of circadian clock genes (CRY1, NR1D1, RORA) and larger left atrial volume were significantly associated with higher atrial high-rate episode burden in patients with AF.

synapsesocial.com/papers/6a13069383732aa7db9ec1d2 https://doi.org/10.3390/diagnostics11010090

Topics

Atrial fibrillation Persistent AF management STEMI management Anticoagulation in AF

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Altered Expression of Circadian Clock Genes in Patients with Atrial Fibrillation Is Associated with Atrial High-Rate Episodes and Left Atrial Remodeling

Discussion

Member takes

Implication

Study Design

Structured PICO

Limitations

Cite This Study

Topics

Altered Expression of Circadian Clock Genes in Patients with Atrial Fibrillation Is Associated with Atrial High-Rate Episodes and Left Atrial Remodeling

Discussion

Member takes

Implication

Study Design

Structured PICO

Limitations

Cite This Study

Also Consider

Topics

Also Consider