What does this research mean for the field?

In post-myocardial infarction patients, left ventricular dilatation at 6 months is more pronounced in end systole for those with baseline LVEF 40-50% compared to those with LVEF 25-39%, and treatment with nisoldipine does not significantly affect this remodelling process. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

January 1, 1999Scandinavian Cardiovascular JournalOpen Access

Left Ventricular Remodelling in Post-myocardial Infarction Patients with Left Ventricular Ejection Fraction 40-50% vs 25-39%. Influence of Nisoldipine Treatment?: An Echocardiographic Substudy from the DEFIANT II Study

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Why the study?

Does nisoldipine improve left ventricular remodelling in post-myocardial infarction patients with LVEF 25-50%?

Population

542 post-infarction patients with LVEF 25-50% without overt heart failure within 13 days following acute…

Comparison

Nisoldipine coat-core (CC) vs Placebo

Design

RCT, randomized

Follow-up

6 months

Authors

KOKoos Lubsen Jan E. OtterstadHospital of the University of Pennsylvania

Discussion

Member takes

Implication

Nisoldipine does not attenuate post-MI LV remodeling; confirms neutral effect on volumes and reinforces ACE inhibitors as preferred therapy.

Structured PICO

Does nisoldipine improve left ventricular remodelling in post-myocardial infarction patients with LVEF 25-50%?

Population

542 post-infarction patients with LVEF 25-50% without overt heart failure within 13 days following acute myocardial infarction (AMI)

Intervention

Nisoldipine coat-core (CC)

Comparator

Placebo

Outcome

Left ventricular (LV) remodelling (LV end diastolic and end systolic volumes) at 6 monthssurrogate

Nisoldipine treatment does not significantly influence left ventricular remodelling 6 months post-myocardial infarction in patients with LVEF 25-50%.

Cite This Study

Koos Lubsen Jan E. Otterstad (1999) studied this question.

synapsesocial.com/papers/6a1306974a30fb84f7a5a73a https://doi.org/10.1080/14017439950141678

Topics

Echocardiography

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Implication

Nisoldipine does not attenuate post-MI LV remodeling; confirms neutral effect on volumes and reinforces ACE inhibitors as preferred therapy.

Left Ventricular Remodelling in Post-myocardial Infarction Patients with Left Ventricular Ejection Fraction 40-50% vs 25-39%. Influence of Nisoldipine Treatment?: An Echocardiographic Substudy from the DEFIANT II Study

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Left Ventricular Remodelling in Post-myocardial Infarction Patients with Left Ventricular Ejection Fraction 40-50% vs 25-39%. Influence of Nisoldipine Treatment?: An Echocardiographic Substudy from the DEFIANT II Study

Discussion

Member takes

Implication

Structured PICO

Cite This Study

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