Why the study?
Does sublingual nifedipine improve left ventricular diastolic function independently of afterload reduction in patients with idiopathic congestive cardiomyopathy?
Population
10 patients with idiopathic congestive cardiomyopathy (ages 28-69, NYHA Class III or IV)
Comparison
10 mg of sublingual nifedipine vs Baseline (pre-administration)
Design
Case_series
Follow-up
6 hours
Authors
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Observation in one case raises possibility of direct compliance improvement; leaves open confirmation in randomized studies of idiopathic cardiomyopathy.
Does sublingual nifedipine improve left ventricular diastolic function independently of afterload reduction in patients with idiopathic congestive cardiomyopathy?
Sublingual nifedipine demonstrates a direct beneficial effect on left ventricular chamber compliance in congestive cardiomyopathy, independent of its afterload-reducing properties.
Percy et al. (1989) studied this question.
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