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May 1, 1984CirculationOpen Access

The dependence of the cardiac effects of nifedipine on the responses of the peripheral vascular system.

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Why the study?

Does nifedipine 20 mg sublingually improve cardiac and peripheral hemodynamics in patients with impaired left ventricular function?

Population

32 patients undergoing cardiac catheterization, including individuals with impaired and normal left…

Comparison

Nifedipine 20 mg sublingually vs Placebo

Design

RCT, randomly assigned

Authors

PKPeter B. KurnikDrexel UniversityPLP A LudbrookWashington University in St. Louis

Discussion

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Implication

Nifedipine supports acute hemodynamic improvement in impaired LV function; confirms afterload reduction as mechanism for preload decrease rather than venous pooling.

Structured PICO

Does nifedipine 20 mg sublingually improve cardiac and peripheral hemodynamics in patients with impaired left ventricular function?

P
Population
32 patients undergoing cardiac catheterization, including individuals with impaired and normal left ventricular function
I
Intervention
Nifedipine 20 mg sublingually
C
Comparator
Placebo
O
Outcome
Cardiac and peripheral hemodynamic responses (including left ventricular end-diastolic pressure, forearm vascular resistance, forearm blood flow, cardiac output, and total systemic resistance)surrogate

Nifedipine reduces left ventricular preload in patients with impaired LV function by improving systolic function in response to afterload reduction, rather than through venous pooling.

Cite This Study

Kurnik et al. (1984) studied this question.

synapsesocial.com/papers/6a7d80555e3bfbb2632080d4https://doi.org/10.1161/01.cir.69.5.963
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Influence of reduction of preload and afterload by nitroglycerin on left ventricular diastolic pressure-volume relations and relaxation in man.1977 · 121 citations
  2. 2Calcium Channel Blocking Agents in the Treatment of Cardiovascular Disorders. Part II: Hemodynamic Effects and Clinical Applications1980 · 543 citations
  3. 3Acute hemodynamic responses to sublingual nifedipine: dependence on left ventricular function.1982 · 140 citations
  4. 4The Effects of Nitroglycerin and Amyl Nitrite on Arteriolar and Venous Tone in the Human Forearm1965 · 430 citations
  5. 5Mechanism of Action of Calcium-Channel-Blocking Agents1982 · 690 citations