Key result
Sublingual nifedipine (20 mg) did not alter intrinsic myocardial stiffness compared to placebo, suggesting its improvement of ventricular performance is due to peripheral arteriodilation.
Why the study?
Does nifedipine alter intrinsic myocardial stiffness in patients undergoing diagnostic cardiac catheterization?
Population
32 patients undergoing diagnostic cardiac catheterization, including subjects with impaired baseline…
Comparison
Nifedipine 20 mg sublingual vs Placebo
Design
RCT, randomly assigned
Follow-up
30 min
Authors
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Nifedipine benefits can be attributed to afterload reduction alone; confirms peripheral vasodilation as primary mechanism in this RCT.
RCT (n=32)
randomly assigned
Does nifedipine alter intrinsic myocardial stiffness in patients undergoing diagnostic cardiac catheterization?
The improved systolic and diastolic performance seen with nifedipine is due to its peripheral arteriodilator effect rather than direct changes to intrinsic myocardial stiffness.
Kurnik et al. (1986) conducted an RCT in patients undergoing diagnostic cardiac catheterization (n=32). nifedipine vs. placebo was evaluated on intrinsic myocardial stiffness. Sublingual nifedipine (20 mg) did not alter intrinsic myocardial stiffness compared to placebo, suggesting its improvement of ventricular performance is due to peripheral arteriodilation.
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