Key result
Sublingual nifedipine (20 mg) did not alter intrinsic myocardial stiffness compared to placebo, suggesting its improvement of ventricular performance is due to peripheral arteriodilation.
Why the study?
Does nifedipine alter intrinsic myocardial stiffness in patients undergoing diagnostic cardiac catheterization?
RCT (n=32)
randomly assigned
Does nifedipine alter intrinsic myocardial stiffness in patients undergoing diagnostic cardiac catheterization?
The improved systolic and diastolic performance seen with nifedipine is due to its peripheral arteriodilator effect rather than direct changes to intrinsic myocardial stiffness.
Authors
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Nifedipine benefits can be attributed to afterload reduction alone; confirms peripheral vasodilation as primary mechanism in this RCT.
Kurnik et al. (1986) conducted an RCT in patients undergoing diagnostic cardiac catheterization (n=32). nifedipine vs. placebo was evaluated on intrinsic myocardial stiffness. Sublingual nifedipine (20 mg) did not alter intrinsic myocardial stiffness compared to placebo, suggesting its improvement of ventricular performance is due to peripheral arteriodilation.